Experience with opioids does not modify the brain network involved in expectations of placebo analgesia.

ABSTRACT: Placebo analgesia (PA) is defined as a psychobiological phenomenon triggered by the information surrounding an analgesic drug instead of its inherent pharmacological properties. PA is hypothesized to be formed through either verbal suggestions or conditioning. The present study aims at disentangling the neural correlates of expectations effects with or without conditioning through prior experience using the model of PA. We addressed this question by recruiting two groups of individuals holding comparable verbally-induced expectations regarding morphine analgesia but either (i) with or (ii) without prior experience with opioids. We then contrasted the two groups' neurocognitive response to acute heat-pain induction following the injection of sham morphine using electroencephalography (EEG).

SUBMITTER: Wicht CA 

PROVIDER: S-EPMC9311217 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature