Impact of surgery and anesthesia during early brain development: A perfect storm.

ABSTRACT: Neonatal surgery and concomitant anesthesia coincide with a timeframe of rapid brain development. The speed and complexity of early brain development superimposed on immature regulatory mechanisms that include incomplete cerebral autoregulation, insufficient free radical scavenging and an immature immune response puts the brain at risk. Brain injury may have long-term consequences for multiple functional domains including cognition, learning skills, and behavior. Neurodevelopmental follow-up studies have noted mild-to-moderate deficits in children who underwent major neonatal surgery and related anesthesia. The present review evaluates neonatal surgery against the background of neurobiological processes that unfold at a pace unparalleled by any other period of human brain development. Firs

SUBMITTER: Keunen K 

PROVIDER: S-EPMC9311405 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature