Therapeutic Role of Vitamin D in Multiple Sclerosis: An Essentially Contested Concept.

ABSTRACT: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system with incredibly intricate etiopathogenesis involving numerous genetic, epigenetic, and environmental risk factors. Major environmental risk factors include ultraviolet (UV) radiation, vitamin D, Epstein-Barr virus (EBV) infection, smoking, and high body mass index (BMI). Vitamin D, in particular, can be viewed as one piece of this puzzle, with various tabs and pockets, occupying a sequential site. In this article, we have briefly discussed the neuroimmunology of MS and the role of vitamin D in regulating immune responses. Various observational studies and clinical trials were reviewed and discussed according to stages of disease activity and course of the disease. The data reviewed in this article imp

SUBMITTER: Fatima M 

PROVIDER: S-EPMC9311493 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature