Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants.

ABSTRACT: The relationship between antibiotic use and Clostridioides difficile (C. difficile) has been well established in adults and older children but remains unclear and is yet to be fully examined in infant populations. This study aimed to determine the separate and cumulative impact from antibiotics and household cleaning products on C. difficile colonization in infants. This study included 1429 infants at 3-4 months of age and 1728 infants at 12 months of age from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. The levels of infant antimicrobial exposure were obtained from hospital birth charts and standardized questionnaires. Infant gut microbiota was characterized by Illumina 16S ribosomal ribonucleic acid (rRNA) gene sequencing. Analysis of

SUBMITTER: Obiakor CV 

PROVIDER: S-EPMC9311587 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature