Inactivation of Bacteria and Residual Antimicrobials in Hospital Wastewater by Ozone Treatment.

ABSTRACT: The emergence and spread of antimicrobial resistance (AMR) has become a persistent problem globally. In this study, an ozone treatment facility was established for an advanced hospital wastewater treatment in a core hospital facility in an urban area in Japan to evaluate the inactivation of antimicrobial-resistant bacteria and antimicrobials. Metagenomic DNA-seq analysis and the isolation of potential extended-spectrum β-lactamase (ESBL)-producing bacteria suggested that ozone exposure for at least 20 min is required for the adequate inactivation of DNA and ESBL-producing bacteria. Escherichia coli and Klebsiella species were markedly susceptible to 20-min ozone exposure, whereas Raoultella ornithinolytica and Pseudomonas putida were isolated even after a

SUBMITTER: Azuma T 

PROVIDER: S-EPMC9311624 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature