The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects.

ABSTRACT: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for cellular regulation against oxidative stress and inflammation, and therefore an attractive therapeutic target. Several organosulfur compounds are reportedly activators of the Nrf2 pathway. Organosulfur compounds constitute an important class of therapeutic agents in medicinal chemistry due to their ability to participate in biosynthesis, metabolism, cellular functions, and protection of cells from oxidative damage. Sulfur has distinctive chemical properties such as a large number of oxidation states and versatility of reactions that promote fundamental biological reactions and redox biochemistry. The presence of sulfur is responsible for the peculiar features of organosulfur compounds which have been

SUBMITTER: Egbujor MC 

PROVIDER: S-EPMC9311638 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature