Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.

ABSTRACT:

Background and purpose

Paclitaxel produces a chemotherapy-induced peripheral neuropathy that persists in 50-60% of cancer patients upon treatment. Evidence from animal models suggests an axonopathy of peripheral A- and C-type fibres that affects their excitability. However, direct effects of paclitaxel on sensory neuron excitability and sexual dimorphism remain poorly understood.

Experimental approach

We used a long-lasting (10 days in vitro) primary culture of rat dorsal root ganglion (DRG) neurons to investigate the time course effect of paclitaxel on the electrical activity of IB4(-) and IB4(+) sensory neurons of female and male adult Wistar rats.

Key results

Paclitaxel strongly and reversibly stimulated spontaneous activity and augmented action potential tonic fir

SUBMITTER: Villalba-Riquelme E 

PROVIDER: S-EPMC9311666 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature