A long-term cohort study of acitretin for prevention of keratinocyte carcinoma in solid organ transplant recipients.

ABSTRACT:

Background

Solid organ transplant recipients (SOTR) are at high risk of keratinocyte carcinoma (KC). Long-term evidence for acitretin as chemoprophylaxis in this population is lacking.

Objective

To determine the benefit of long-term acitretin for KC chemoprevention in SOTR.

Methods

A retrospective cohort study of SOTR treated with acitretin at an Australian transplant dermatology clinic was performed. General estimating equations were used to evaluate change in rates of histologically confirmed KC in the 6-12 months prior to acitretin and following a minimum 6 months of treatment. A control group of patients within the same service was included, comprising SOTR who were not treated with acitretin.

Results

Twenty-two patients received acitretin treatment for at

SUBMITTER: Allnutt KJ 

PROVIDER: S-EPMC9311671 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature