Parental smoking, type 1 diabetes, and islet autoantibody positivity in the offspring: A systematic review and meta-analysis.

ABSTRACT:

Aims

Our aim was to synthesize current evidence on the association between parental smoking and incidence of type 1 diabetes and islet autoantibody positivity (IA) in the offspring by conducting a systematic review and meta-analysis.

Methods

We searched Medline, Embase, and Cochrane Library until January 21, 2021, for human studies with parental tobacco use as exposure, type 1 diabetes or IA as outcome, and hazard, risk, or odds ratios as effect estimates. Summary relative risks (RR) and 95% confidence intervals (CI) were estimated with random-effects models. Heterogeneity was quantified with the I²  statistic, bias with the ROBINS-I tool, and the certainty of evidence with the GRADE tool.

Results

We identified 535 records of which 23 were eligible includin

SUBMITTER: Edstorp J 

PROVIDER: S-EPMC9311676 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature