Risk of primary liver cancer in acute hepatic porphyria patients: A matched cohort study of 1244 individuals.

ABSTRACT:

Background

The acute hepatic porphyrias (AHP) are associated with a risk of primary liver cancer (PLC), but risk estimates are unclear, and what AHP characteristics that predict PLC risk are unknown. In this register-based, matched cohort study, we assessed the PLC risk in relation to biochemical and clinical porphyria severity, genotype, age, and sex.

Methods

All patients in the Swedish porphyria register with acute intermittent porphyria (AIP), variegate porphyria (VP), or hereditary coproporphyria (HCP) during 1987-2015 were included. This AHP cohort was compared with age-, sex-, and county-matched reference individuals from the general population. National register-based hospital admissions for AHP were used to indicate the clinical severity. For AIP, the most common AHP

SUBMITTER: Lissing M 

PROVIDER: S-EPMC9311710 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature