Melatonin Prevents NaAsO₂-Induced Developmental Cardiotoxicity in Zebrafish through Regulating Oxidative Stress and Apoptosis.

ABSTRACT: Melatonin is an indoleamine hormone secreted by the pineal gland. It has antioxidation and anti-apoptosis effects and a clear protective effect against cardiovascular diseases. Our previous studies demonstrated that embryonic exposure to sodium arsenite (NaAsO₂) can lead to an abnormal cardiac development. The aim of this study was to determine whether melatonin could protect against NaAsO₂-induced generation of reactive oxygen species (ROS), oxidative stress, apoptosis, and abnormal cardiac development in a zebrafish (Danio rerio) model. We found that melatonin decreased NaAsO₂-induced zebrafish embryonic heart malformations and abnormal heart rates at a melatonin concentration as low as 10^-9 mol/L. The NaAsO₂-induced oxidative stress

SUBMITTER: Yan R 

PROVIDER: S-EPMC9311860 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature