Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk.
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SUBMITTER: D'Amuri A
PROVIDER: S-EPMC9311907 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk.
D'Amuri Andrea A Sanz Juana Maria JM Lazzer Stefano S Pišot Rado R Šimunič Bostjan B Biolo Gianni G Zuliani Giovanni G Gasparini Mladen M Narici Marco M Grassi Bruno B Reggiani Carlo C Dalla Nora Edoardo E Passaro Angelina A
Biology 20220630 7
The detrimental effect of physical inactivity on muscle characteristics are well known. Irisin, an exercise-induced myokine cleaved from membrane protein fibronectin type III domain-containing protein-5 (FNDC5), mediates at least partially the metabolic benefits of exercise. This study aimed to assess the interplay between prolonged inactivity, circulating irisin, muscle performance, muscle fibers characteristics, as well as the FNDC5 gene expression (FNDC5ge) in muscle and adipose tissue among ...[more]
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