An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research

ABSTRACT: Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism. Alginate–fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based o

SUBMITTER: An R 

PROVIDER: S-EPMC9311974 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature