Resistance to Obesity in SOD1 Deficient Mice with a High-Fat/High-Sucrose Diet.

ABSTRACT: Metabolic syndrome (Mets) is an important condition because it may cause stroke and heart disease in the future. Reactive oxygen species (ROSs) influence the pathogenesis of Mets; however, the types of ROSs and their localization remain largely unknown. In this study, we investigated the effects of SOD1, which localize to the cytoplasm and mitochondrial intermembrane space and metabolize superoxide anion, on Mets using SOD1 deficient mice (SOD1^-/-). SOD1^-/- fed on a high-fat/high-sucrose diet (HFHSD) for 24 weeks showed reduced body weight gain and adipose tissue size compared to wild-type mice (WT). Insulin secretion was dramatically decreased in SOD1^-/- fed on HFHSD even though blood glucose levels were similar to WT. Ambulatory oxygen consumption was acc

SUBMITTER: Sato A 

PROVIDER: S-EPMC9312060 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature