In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition.

ABSTRACT:

Background

in patients with chronic kidney disease (CKD), the inflammatory and pro-oxidant milieu may contribute to malnutrition development. In this study, we investigated the relationship between inflammation, advanced glycation end-products (AGEs), and their receptors (RAGEs) with malnutrition in CKD patients.

Methods

we evaluated 117 patients. AGEs were quantified by fluorescence intensity using a fluorescence spectrophotometer, soluble RAGEs isoforms, and inflammatory interleukins by ELISA. Malnutrition was assessed by a malnutrition inflammation score.

Results

mean age was 80 ± +11 years, eGFR was 25 ± +11 mL/min/1.73 m² and BMI was 28 ± 5 Kg/m². Malnourished individuals were older, had lower estimated protein intake (nPCR 0.65 ± 0.2 vs. 0.

SUBMITTER: Caldiroli L 

PROVIDER: S-EPMC9312066 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature