A Census of Human Methionine-Rich Prion-like Domain-Containing Proteins.

ABSTRACT: Methionine-rich prion-like proteins can regulate liquid-liquid phase separation processes in response to stresses. To date, however, very few proteins have been identified as methionine-rich prion-like. Herein, we have performed a computational survey of the human proteome to search for methionine-rich prion-like domains. We present a census of 51 manually curated methionine-rich prion-like proteins. Our results show that these proteins tend to be modular in nature, with molecular sizes significantly greater than those we would expect due to random sampling effects. These proteins also exhibit a remarkably high degree of spatial compaction when compared to average human proteins, even when protein size is accounted for. Computational evidence suggests that such a high degree of compactness

SUBMITTER: Aledo JC 

PROVIDER: S-EPMC9312190 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature