Sinapicacid Inhibits Group IIA Secretory Phospholipase A₂ and Its Inflammatory Response in Mice.

ABSTRACT: Human Group IIA secreted phospholipase A₂ (sPLA₂-IIA) enzyme plays a crucial role in several chronic inflammatory diseases such asasthma, atherosclerosis, gout, bronchitis, etc. Several studies showed that the antioxidants exert an anti-inflammatory function by inhibiting the sPLA₂-IIA enzyme. Hence, the present study evaluated an antioxidant molecule, sinapic acid, for sPLA₂-IIA inhibition as an anti-inflammatory function. Initially, the antioxidant efficacy of sinapic acid was evaluated, and it showed greater antioxidant potency. Further, sinapic acid inhibited 94.4 ± 4.83% of sPLA₂-IIA activity with an IC₅₀ value of 4.16 ± 0.13 µM. The mode of sPLA₂-IIA inhibition was examined by increasing the substrate concen

SUBMITTER: Giresha AS 

PROVIDER: S-EPMC9312209 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature