PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis

ABSTRACT:

Simple Summary

Myocarditis is the inflammation of the heart muscle, and viral infections are a common cause of this disease. Myocarditis in some patients can progress to dilated cardiomyopathy (DCM). The mouse model of coxsackievirus B3 (CVB3) is commonly used to understand this disease progression in DCM patients. In this paper, we have attempted to analyze antibodies for heart antigens that could be produced as a result of heart damage in animals infected with CVB3 using a technique called Phage ImmunoPrecipitation Sequencing (PhIP-Seq). The analyses led us to identify antibodies for several proteins that were not previously reported that may have relevance to human disease.

Abstract

Enteroviruses such as group B coxsackieviruses (CVB) are commonly suspected as causes o

SUBMITTER: Rasquinha M 

PROVIDER: S-EPMC9312229 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature