Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.

ABSTRACT: Individuals with Down syndrome show cellular and clinical features of dysregulated aging of the immune system, including a shift from naïve to memory T cells and increased incidence of autoimmunity. However, a quantitative understanding of how various immune compartments change with age in Down syndrome remains lacking. Here, we performed deep immunophenotyping of a cohort of individuals with Down syndrome across the life span, selecting for autoimmunity-free individuals. We simultaneously interrogated age- and sex-matched healthy controls and people with type 1 diabetes as a representative autoimmune disease. We built an analytical software, IMPACD (Iterative Machine-assisted Permutational Analysis of Cytometry Data), that enabled us to rapidly identify many features of immune dysregulati

SUBMITTER: Lambert K 

PROVIDER: S-EPMC9312285 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature