Occurrence of Serratia marcescens Carrying bla_IMP-26 and mcr-9 in Southern China: New Insights in the Evolution of Megaplasmid IMP-26.

ABSTRACT: The spread of multidrug-resistant enterobacteria strains has posed a significant concern in public health, especially when the strain harbors metallo-beta-lactamase (MBL)-encoding and mobilized colistin resistance (mcr) genes as such genetic components potentially mediate multidrug resistance. Here we report an IncHI2/2A plasmid carrying bla_IMP-26 and mcr-9 in multidrug-resistant Serratia marcescens human isolates YL4. Antimicrobial susceptibility testing was performed by the broth microdilution method. According to the results, S. marcescens YL4 was resistant to several antimicrobials, including β-lactams, fluorquinolones, sulfanilamide, glycylcycline, and aminoglycosides, except for amikacin. To investigate the plasmid further, we conducted w

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC9312351 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature