Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients.

ABSTRACT:

Objective

Patients admitted to the Intensive Care Unit (ICU) oftentimes show immunological signs of immune suppression. Consequently, immune stimulatory agents have been proposed as an adjunctive therapy approach in the ICU. The objective of this study was to determine the relationship between the degree of immune suppression and systemic inflammation in patients shortly after admission to the ICU. Design: An observational study in two ICUs in the Netherlands.

Methods

The capacity of blood leukocytes to produce cytokines upon stimulation with lipopolysaccharide (LPS) was measured in 77 patients on the first morning after ICU admission. Patients were divided in four groups based on quartiles of LPS stimulated tumor necrosis factor (TNF)-α release, reflecting increasing extent

SUBMITTER: Brands X 

PROVIDER: S-EPMC9312372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature