Impact of Ca²⁺-Induced PI(4,5)P₂ Clusters on PH-YFP Organization and Protein-Protein Interactions.

ABSTRACT: Despite its low abundance, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) is a key modulator of membrane-associated signaling events in eukaryotic cells. Temporal and spatial regulation of PI(4,5)P₂ concentration can achieve localized increases in the levels of this lipid, which are crucial for the activation or recruitment of peripheral proteins to the plasma membrane. The recent observation of the dramatic impact of physiological divalent cation concentrations on PI(4,5)P₂ clustering, suggests that protein anchoring to the plasma membrane through PI(4,5)P₂ is likely not defined solely by a simple (monomeric PI(4,5)P₂)/(protein bound PI(4,5)P₂) equilibrium, but instead depends on complex protein interactions with PI(4,5)

SUBMITTER: Borges-Araujo L 

PROVIDER: S-EPMC9312469 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature