Electrochemical Biosensors Based on Convectively Assembled Colloidal Crystals.

ABSTRACT: Rapid, sensitive, selective and portable virus detection is in high demand globally. However, differentiating non-infectious viral particles from intact/infectious viruses is still a rarely satisfied sensing requirement. Using the negative space within monolayers of polystyrene (PS) spheres deposited directly on gold electrodes, we fabricated tuneable nanochannels decorated with target-selective bioreceptors that facilitate the size-selective detection of intact viruses. Detection occurred through selective nanochannel blockage of diffusion of a redox probe, [Fe(CN)₆]^3/4-, allowing a quantifiable change in the oxidation current before and after analyte binding to the bioreceptor immobilised on the spheres. Our model system involved partial surface passivation of the m

SUBMITTER: Shiohara A 

PROVIDER: S-EPMC9312794 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature