Cortisol as an Independent Predictor of Unfavorable Outcomes in Hospitalized COVID-19 Patients.

ABSTRACT: Most cases of COVID-19 are non-severe, but some patients require urgent hospital care. In the past, it has been established that adrenal hyperactivity predicts poorer prognosis in severely ill patients. We wanted to verify if cortisol levels can be tied to clinical outcomes and the degree of inflammation in hospitalized COVID-19 patients. We recruited 180 adult patients with PCR-confirmed COVID-19. The group was divided into smaller subgroups based on the glucocorticoid treatment status; the subgroups were evaluated in three separate time points. The assessment involved hormonal function (cortisol, ACTH), inflammatory markers, and occurrence of the pre-selected endpoints (death, hospitalization ≥10 days, non-invasive ventilation or high-flow oxygenation, mechanical ventilation, vasopressor

SUBMITTER: Swiatkowska-Stodulska R 

PROVIDER: S-EPMC9313159 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature