Association between Advanced Glycation End-Products and Sarcopenia in Patients with Chronic Kidney Disease.

ABSTRACT:

Background

In patients with chronic kidney disease (CKD), there is an overproduction and accumulation of advanced glycation end-products (AGEs). Since AGEs may have detrimental effects on muscular trophism and performance, we evaluated whether they may contribute to the onset of sarcopenia in CKD patients.

Methods

We enrolled 117 patients. The AGEs were quantified by fluorescence intensity using a fluorescence spectrophotometer and soluble receptor for AGE (sRAGE) isoforms by ELISA. As for the sarcopenia definition, we used the European Working Group on Sarcopenia in Older People (EWGSOP2) criteria.

Results

The average age was 80 ± 11 years, 70% were males, and the mean eGFR was 25 + 11 mL/min/1.73 m². Sarcopenia was diagnosed in 26 patients (with a prevale

SUBMITTER: Molinari P 

PROVIDER: S-EPMC9313160 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature