A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders.

ABSTRACT:

Background

Tic disorders (TDs), including Tourette syndrome, are childhood-onset neuropsychiatric disorders characterized by motor and/or vocal tics that commonly affect children's physical and mental health. The pathogenesis of TDs may be related to abnormal neurotransmitters in the cortico-striatal-thalamo-cortical circuitry, especially dopaminergic, glutamatergic, and serotonergic neurotransmitters. The purpose of this study was to preliminarily investigate the differences in the three types of neurotransmitters in plasma and urine between children with TD and healthy children.

Methods

We collected 94 samples of plasma and 69 samples of urine from 3-12-year-old Chinese Han children with TD before treatment. The plasma and urine of the same number of healthy Chinese Han ch

SUBMITTER: Qian QQ 

PROVIDER: S-EPMC9313232 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature