Label-free differentiation of human pancreatic cancer, pancreatitis, and normal pancreatic tissue by molecular spectroscopy.

ABSTRACT:

Significance

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths with a best median survival of only 40 to 50 months for localized disease despite multimodal treatment. The standard tissue differentiation method continues to be pathology with histological staining analysis. Microscopic discrimination between inflammatory pancreatitis and malignancies is demanding.

Aim

We aim to accurately distinguish native pancreatic tissue using infrared (IR) spectroscopy in a fast and label-free manner.

Approach

Twenty cryopreserved human pancreatic tissue samples were collected from surgical resections. In total, more than 980,000 IR spectra were collected and analyzed using aMATLAB package. For differentiation of PDAC, pancreatitis, and normal ti

SUBMITTER: Teske C 

PROVIDER: S-EPMC9313287 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature