Targeted Arginine Metabolism Therapy: A Dilemma in Glioma Treatment.

ABSTRACT: Efforts in the treatment of glioma which is the most common primary malignant tumor of the central nervous system, have not shown satisfactory results despite a comprehensive treatment model that combines various treatment methods, including immunotherapy. Cellular metabolism is a determinant of the viability and function of cancer cells as well as immune cells, and the interplay of immune regulation and metabolic reprogramming in tumors has become an active area of research in recent years. From the perspective of metabolism and immunity in the glioma microenvironment, we elaborated on arginine metabolic reprogramming in glioma cells, which leads to a decrease in arginine levels in the tumor microenvironment. Reduced arginine availability significantly inhibits the proliferation, activati

SUBMITTER: Hou X 

PROVIDER: S-EPMC9313538 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature