Synthetic 4DCT(MRI) lung phantom generation for 4D radiotherapy and image guidance investigations.

ABSTRACT:

Purpose

Respiratory motion is one of the major challenges in radiotherapy. In this work, a comprehensive and clinically plausible set of 4D numerical phantoms, together with their corresponding "ground truths," have been developed and validated for 4D radiotherapy applications.

Methods

The phantoms are based on CTs providing density information and motion from multi-breathing-cycle 4D Magnetic Resonance imagings (MRIs). Deformable image registration (DIR) has been utilized to extract motion fields from 4DMRIs and to establish inter-subject correspondence by registering binary lung masks between Computer Tomography (CT) and MRI. The established correspondence is then used to warp the CT according to the 4DMRI motion. The resulting synthetic 4DCTs are called 4DCT(MRI)s. Valida

SUBMITTER: Duetschler A 

PROVIDER: S-EPMC9313613 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature