The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross-over trial.

ABSTRACT:

Background

The popularity of the gluten-free diet and sales of gluten-free products have increased immensely.

Aims

To investigate whether gluten induces gastrointestinal symptoms, measured by self-reported questionnaires, as well as mental health symptoms in adolescents from a population-based cohort.

Methods

The eligible participants (n = 273) were recruited from a population-based cohort of 1266 adolescents and had at least four different gastrointestinal symptoms. Phase one (n = 54) was a run-in phase where the participants lived gluten-free for 2 weeks. If they improved they continued to phase 2 (n = 33), a blinded randomised cross-over trial. Participants were blindly randomised either to start with 7 days of gluten, eating two granola bars containing 10 g of glu

SUBMITTER: Crawley C 

PROVIDER: S-EPMC9313792 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature