A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.

ABSTRACT:

Background

Impaired eyeblink conditioning is often cited as evidence for cerebellar dysfunction in isolated dystonia yet the results from individual studies are conflicting and underpowered.

Objective

To systematically examine the influence of dystonia, dystonia subtype, and clinical features over eyeblink conditioning within a statistical model which controlled for the covariates age and sex.

Methods

Original neurophysiological data from all published studies (until 2019) were shared and compared to an age- and sex-matched control group. Two raters blinded to participant identity rescored all recordings (6732 trials). After higher inter-rater agreement was confirmed, mean conditioning per block across raters was entered into a mixed repetitive measures model.

Resu

SUBMITTER: Sadnicka A 

PROVIDER: S-EPMC9313805 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature