Duration of use and outcomes among people with opioid use disorder initiating methadone and buprenorphine in Ontario: a population-based propensity-score matched cohort study.

ABSTRACT:

Aims

To characterize comparative risks and benefits of methadone versus buprenorphine/naloxone in a contemporary cohort where the unregulated drug supply is dominated by fentanyl.

Design, setting and participants

Population-based propensity-score matched cohort study conducted in Ontario, Canada among people aged 18+ initiating opioid agonist therapy (OAT) for an opioid use disorder between October 2016 and December 2018 (n = 18 880).

Intervention

Initiation of methadone versus buprenorphine/naloxone.

Measurements

The primary outcome was opioid overdose (fatal and non-fatal) while on treatment, with secondary outcomes including opioid overdose (first 30 days of treatment), treatment discontinuation, health-care interactions related to treatment of opioid use di

SUBMITTER: Gomes T 

PROVIDER: S-EPMC9313829 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature