Expanded Mercaptocalixarenes: A New Kind of Macrocyclic Ligands for Stabilization of Polynuclear Thiolate Clusters.

ABSTRACT: The syntheses and properties of expanded 4-tert-butyl-mercaptocalix[4]arenes, in which the methylene linkers are replaced by -CH₂ NRCH₂ - or -CH₂ NRCH₂ - and -CH₂ NRCH₂ CH₂ CH₂ NRCH₂ - units, are described. The new macrocycles were obtained in a step-wise manner, utilizing fully protected, i. e. S-alkylated, derivatives of the oxidation-sensitive thiophenols in the cyclisation steps. Reductive cleavage of the macrobicyclic or macrotricyclic intermediates (6, 7, 11) afforded the free thiophenols (H₄ 8, H₄ 9, and H₄ 12) in preparative yields as their hydrochloride salts. The protected proligands can exist in two conformations, resembling the "cone" and "1,3-alte

SUBMITTER: Schleife F 

PROVIDER: S-EPMC9313869 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature