Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: Impact on cognition.

ABSTRACT: Patients suffering from anorexia nervosa (AN) display altered neural activity, morphological, and functional connectivity in the fronto-striatal circuit. In addition, hypoglutamatergic transmission and aberrant excitability of the medial prefrontal cortex (mPFC) observed in AN patients might underpin cognitive deficits that fuel the vicious cycle of dieting behavior. To provide a molecular mechanism, we employed the activity-based anorexia (ABA) rat model, which combines the two hallmarks of AN (i.e., caloric restriction and intense physical exercise), to evaluate structural remodeling together with alterations in the glutamatergic signaling in the mPFC and their impact on temporal memory, as measured by the temporal order object recognition (TOOR) test. Our data indicate that the combinat

SUBMITTER: Mottarlini F 

PROVIDER: S-EPMC9313878 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature