Stability of amino acids, free and acyl-carnitine in stored dried blood spots.

ABSTRACT:

Background

Newborn screening of inborn errors of metabolism using tandem mass spectrometry has become a public health strategy in many developed countries. Retrospective analyses using stored dried blood specimens have been limited, mainly due to a lack of biochemical information on the long-term stability of acylcarnitines and amino acids in stored specimens. We studied the characteristic profiles of the stability of amino acid, free carnitine, and acyl carnitines in dried blood specimens stored in a refrigerator after newborn screening.

Methods

Dried blood specimens from 198 healthy newborns, which had been stored in a refrigerator at 5 °C after newborn screening, were prospectively subjected to tandem mass spectrometry analyses after 1, 3, 6 months, 1 and 2 years of stora

SUBMITTER: Shimada Y 

PROVIDER: S-EPMC9313883 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature