Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated-A Systematic Review.

ABSTRACT:

Background

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation-induced damage repair that is characterized by photosensitivity and a propensity for developing, among many others, skin cancers at an early age. This systematic review focused on the correlation between the clinical, pathological, and genetic aspects of XP and skin cancer.

Methods

A systematic review was conducted through a literature search of online databases PubMed, Cochrane Library, SciELO, and Google Scholar. Search terms were "Xeroderma pigmentosum", "XP", "XPC", "Nucleotide excision repair", "NER", "POLH", "Dry pigmented skin", and "UV sensitive syndrome" meshed with the terms "Skin cancer", "Melanoma", and "NMSC".

Results

After 504 abstracts screening, 13 full-text ar

SUBMITTER: Brambullo T 

PROVIDER: S-EPMC9313971 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature