A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP⁵⁺, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line.

ABSTRACT: We have employed a redox-active MnP (MnTnBuOE-2-PyP⁵⁺, Mn(III) meso-tetrakis (N-n-butoxyethylpyridinium-2-yl) porphyrin) frequently identified as superoxide dismutase mimic or BMX-001, to explore the redox status of normal ovarian cell in relation to two ovarian cancer cell lines: OV90 human serous ovarian cancer cell and chemotherapy-resistant OV90 cell (OVCD). We identified that OVCD cells are under oxidative stress due to high hydrogen peroxide (H₂O₂) levels and low glutathione peroxidase and thioredoxin 1. Furthermore, OVCD cells have increased glycolysis activity and mitochondrial respiration when compared to immortalized ovarian cells (hTER7) and parental cancer cells (OV90). Our goal was to study how ovarian cell growth depends upon the redox state o

SUBMITTER: Chaiswing L 

PROVIDER: S-EPMC9313984 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature