The interaction between iodinated X-ray contrast agents and macrocyclic GBCAs provides a signal enhancement in T₁ -weighted MR images: Insights into the renal excretion pathways of Gd-HPDO3A and iodixanol in healthy mice.

ABSTRACT:

Purpose

This work aims to investigate the supramolecular binding interactions that occur between iodinated X-ray contrast agents (CAs) and macrocyclic gadolinium (Gd)-based MRI contrast agents (GBCAs). This study provides some new insights in the renal excretion pathways of the two types of imaging probes.

Methods

The water-proton relaxivities (r₁ ) of clinically approved macrocyclic and linear GBCAs have been measured in the presence of different iodinated X-ray contrast agents at different magnetic field strengths in buffer and in serum. The in vivo MRI and X-ray CT of mice injected with either Gd-HPDO3A or a Gd-HPDO3A + iodixanol mixture were then acquired to assess the biodistribution of the two probes.

Results

A significant increase in r₁ (u

SUBMITTER: Di Gregorio E 

PROVIDER: S-EPMC9314041 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature