Microbiota of the first-pass meconium and subsequent atopic and allergic disorders in children.

ABSTRACT:

Background

Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first-pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about any relationship with allergic disease development.

Objective

We investigated whether the bacterial composition of the first-pass meconium is associated with the development of allergic diseases before 4 years of age.

Methods

Prospective birth cohort study. Bacterial composition of first-pass meconium was analysed using bacterial 16S rRNA gene amplicon sequencing. Atopic and allergic diseases were evaluated via online survey or telephone to age 4 years, based on the Internatio

SUBMITTER: Kielenniva K 

PROVIDER: S-EPMC9314137 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature