A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts.

ABSTRACT: SARS-CoV-2, the novel coronavirus behind the COVID-19 pandemic, is acquiring new mutations in its genome. Although some mutations provide benefits to the virus against human immune response, others may result in their reduced pathogenicity and virulence. By analyzing more than 3000 high-coverage, complete sequences deposited in the GISAID database up to April 2020, here I report the uniqueness of the 28881-28883: GGG > AAC trinucleotide-bloc mutation in the SARS-CoV-2 genome that results in two substrains, described here as SARS-CoV-2g (28881-28883: GGG genotype) and SARS-CoV-2a (28881-28883: AAC genotype). Computational analysis and literature review suggest that this bloc mutation would bring 203-204: RG (arginine-glycine)>KR (lysine-arginine) amino acid changes in the nucleocapsid (N) p

SUBMITTER: Ayub M 

PROVIDER: S-EPMC9314171 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature