BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea.

ABSTRACT: Often acute damage to the cornea initiates drastic tissue remodeling, resulting in fibrotic scarring that disrupts light transmission and precedes vision impairment. Very little is known about the factors that can mitigate fibrosis and promote scar-free cornea wound healing. We previously described transient myofibroblast differentiation during non-fibrotic repair in an embryonic cornea injury model. Here, we sought to elucidate the mechanistic regulation of myofibroblast differentiation during embryonic cornea wound healing. We found that alpha-smooth muscle actin (αSMA)-positive myofibroblasts are superficial and their presence inversely correlates with wound closure. Expression of TGFβ2 and nuclear localization of pSMAD2 were elevated during myofibroblast induction. BMP3 and BMP7 were l

SUBMITTER: Spurlin JW 

PROVIDER: S-EPMC9314337 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature