Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC9314371 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Wang Wenjuan W Ren Jinqi J Song Weiye W Zhang Yong Y Feng Wei W
Nature communications 20220725 1
Autoinhibition of kinesin-3 ensures the proper spatiotemporal control of the motor activity for intracellular transport, but the underlying mechanism remains elusive. Here, we determine the full-length structure of kinesin-3 KLP-6 in a compact self-folded state. Unexpectedly, all the internal coiled-coil segments and domains in KLP-6 cooperate to successively lock down the neck and motor domains. The first coiled-coil segment is melted into several short helices that work with the motor domain t ...[more]