Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin.

ABSTRACT: The adrenal gland provides an important function by integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ capsule. It is the central organ of the stress response system and has been implicated in numerous stress-related disorders. While for other diseases, regeneration of healthy organ tissue has been aimed at such approaches are lacking for endocrine diseases - with the exception of type-I-diabetes. Moreover, adrenal tumor formation is very common, however, appropriate high-throughput applications reflecting the high heterogeneity and furthermore relevant 3D-structures in vitro are still widely lacking. Recently, we have initiated the development of standardized multidimensional models of a variety of endocrine cell/tissue sources in a new multiwell-

SUBMITTER: Bornstein S 

PROVIDER: S-EPMC9314441 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature