Association between TNFi anti-drug antibodies, smoking, and disease activity in patients with inflammatory arthritis: Results from a Norwegian cross-sectional observational study.

ABSTRACT:

Introduction

We aimed to compare demographics and clinical characteristics between patients with inflammatory arthritis (IA) with vs. without neutralizing anti-drug antibodies (nADAb) against tumor necrosis factor inhibitors (TNFi). A secondary aim of the study was to explore if current smokers were more frequently nADAb-positive.

Methods

TNFi-treated outpatients with IA were recruited and a broad range of disease activity measures were assessed. nADAb were assessed using a reporter gene assay. Comparisons between nADAb-positive and -negative patients were done in unadjusted analyses as well as in adjusted logistic regression and general linear models.

Results

A total of 282 patients with IA currently under treatment with TNFi were included. nADAb were identified in 1

SUBMITTER: Michelsen B 

PROVIDER: S-EPMC9314485 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature