Real-World Effectiveness of Belimumab in Systemic Lupus Erythematosus: A Systematic Literature Review.

ABSTRACT:

Introduction

Belimumab is a recombinant human monoclonal antibody that binds to soluble B-lymphocyte stimulator and inhibits its biological activity. Since receiving approvals for the treatment of systemic lupus erythematosus (SLE), several observational studies have investigated the effectiveness of belimumab in the real-world setting. This study reports a systematic review and meta-analysis of the literature to evaluate the real-world effectiveness of belimumab for the treatment of SLE.

Methods

A literature search following PRISMA Guidelines and limited to studies in English was performed (2014-2020) to identify relevant studies reporting effectiveness outcomes of belimumab in patients with SLE. A modified version of the Newcastle-Ottawa Scale was used to assess study qual

SUBMITTER: Huang SP 

PROVIDER: S-EPMC9314515 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature