Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.

ABSTRACT:

Purpose

In chemical exchange saturation transfer imaging, saturation effects between - 2 to - 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previous work on NOEs in human stroke used an analysis model that combined NOEs and semisolid MT; however their combination might feasibly have reduced sensitivity to changes in NOEs. The aim of this study was to explore the information a 4-pool Bloch-McConnell model provides about the NOE contribution in ischemic stroke, contrasting that with an intentionally approximate 3-pool model.

Methods

MRI data from 12 patients presenting with ischemic stroke were retrospectively analyzed, as well as from six animals induced with an ischemic lesion. Two Bloch-McConnell models (4 poo

SUBMITTER: Msayib Y 

PROVIDER: S-EPMC9314583 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature