Hormone therapy and disease activity in Danish women with multiple sclerosis: A population-based cohort study.

ABSTRACT:

Background and purpose

Sex differences in multiple sclerosis (MS) prevalence and disease course are thought to be driven by hormones. Exogenous exposure to estrogens may affect MS disease course. Thus, our aim was to investigate the association between hormone therapy (HT) and disease activity and disability accrual among women with MS.

Methods

A register-based cohort study was conducted with prospectively enrolled cases from the Danish MS registry. Information on hormone exposure was retrieved from the National Prescription Registry. Outcomes were relapse rate, relapse rate ratio, recurrent relapses, 6-month confirmed and sustained Expanded Disability Status Scale (EDSS) milestones 4 and 6, and recurrent EDSS worsening.

Results

In all, 3325 women were eligible for an

SUBMITTER: Kopp TI 

PROVIDER: S-EPMC9314629 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature