Nasal administration of a probiotic assemblage in allergic rhinitis: A randomised placebo-controlled crossover trial.

ABSTRACT:

Background

Topical probiotics have been suggested as a treatment option for allergic rhinitis, as they may skew the immune response towards a beneficial type-1 non-allergic profile. So far observations in man have exclusively involved oral intake. The aim of this study was to examine whether a topical/nasal administration of a probiotic assemblage (PA) affects quality of life, symptoms and signs of allergic rhinitis in a nasal allergen challenge (NAC) model.

Methods

In a placebo-controlled and crossover design, 24 patients with seasonal allergic rhinitis were randomised to topical/nasal administration with a PA of Lactobacillus rhamnosus SP1, Lactobacillus paracasei 101/37 and Lactococcus lactis L1A or placebo for 3 weeks. Participants and investigators were blind to treatme

SUBMITTER: Martensson A 

PROVIDER: S-EPMC9314659 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature