Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis.

ABSTRACT:

Background and objective

Coal mine dust has a complex and heterogeneous chemical composition. It has been suggested that coal particle chemistry plays a critical role in determining the pathogenesis of coal workers' pneumoconiosis (CWP). In this study, we aimed to establish the association between the detrimental cellular response and the chemical composition of coal particles.

Methods

We sourced 19 real-world coal samples. Samples were crushed prior to use to minimize the impact of particle size on the response and to ensure the particles were respirable. Key chemical components and inorganic compounds were quantified in the coal samples. The cytotoxic, inflammatory and pro-fibrotic responses in epithelial cells, macrophages and fibroblasts were assessed following 24 h of e

SUBMITTER: Song Y 

PROVIDER: S-EPMC9314662 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature