Persistence of parental-reported asthma at early ages: A longitudinal twin study.

ABSTRACT:

Background

Currently, we cannot predict whether a pre-school child with asthma-like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of pre-school to school-age asthma. We examined to what extent genetic and environmental factors contribute to persistence of asthma-like symptoms at ages 3 to asthma at age 7 using a bivariate genetic model for longitudinal twin data.

Methods

We performed a cohort study in monozygotic and dizygotic twins from the Netherlands Twin Register (NTR, n = 21,541 twin pairs). Bivariate genetic models were fitted to longitudinal data on asthma-like symptoms reported by parents at age 3 and 7 years to estimate the contribution of genetic and environment

SUBMITTER: Slob EMA 

PROVIDER: S-EPMC9314674 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature